Nov 18, 2025
3 min read
In October in Paris, the conference of the European AIDS Society (EACS) highlighted the development of dual drugs, which promise to make life easier for people living with HIV.But what is dual therapy?How effective?What are the conditions to take advantage of it?Points in 9 questions.HIV: what is dual therapy?How effective?What are the conditions to take advantage of it?Points in 9 questions.
In October, in Paris, the European AIDS Organization AIDS (AIDS, So What Is The Only Treatment? How Can It Be Done? What Conditions Should We Benefit From?) 9 questions.
What is dual therapy?
A new way to treat AIDS has been in development for about ten years.As its name shows, it is based on the molecules of different students (there is no traditional treatment. Reduce the number of ARV molecules but reduce the number of doses of ARV: from every day to four or five days per professor, expert Christine Katlama at the hospital.
What options are already available?
Three main dual therapies have been validated and are now recommended by French and European councils."Two are in the form of 2 in 1 tablets that must be taken daily: Dovat®, which is used in the Antiretroviral War and rilpivirine is a "dolkivirites therapy, which is the "double therapy" injab, accessible from now on The combination of Cabrocabravirovir: 2020: (Vocabra®) and rilpivirine (rekambys®),which is administered by intramuscular injection every 2 months," indicates the infected doctor at the Hôtel-Dieu hospital in Paris.
What benefits?
Going from three to two antiretroviral drugs could limit the side effects and toxicity of these molecules."Triple therapy has extended the life expectancy of people living with HIV (PLHIV), meaning they can now be exposed to antiretroviral drugs for decades. However, as with any drug, these drugs may also have beneficial effects (headaches, digestive disturbances, etc.) and toxicities (nephrotoxicity, osteoporosis, etc.). Treatment compliance can be improved. All of these are not required under HIV Control."
Does anyone have any suggestions?
A doctor specializing in HIV is the doctor dedicated to the hospital's gambling environment every year."Specialists visiting the scientific federation, therefore, to know the methods of treatment, offer treatment assistance", Dr.
Who can benefit from this?
In general, there is plhiv infected with arv for 6 months, as suggested by the French proposal, and there is no resistance to introduction (ini) or rootless charity (nnrti).There are two classes in which arv is used for both treatment.This means that both treatments can be taken from the beginning of treatment, and therefore for people with new disease, the two treatments combining dolutegravir and lamivudine can be taken.“This dual therapy was the only treatment evaluated in treatment-naive plhiv,” Dr. Palich said.PLHIV candidates for dual treatment must then not be chronically infected with hepatitis B virus (hbv).And for good reason: “Some ARVs against HIV used in the treatment of tripir, house alafovir or emtricitabine, are active against hbv.
How many people benefit from treatment for PLHIV?
About 20%, or one in four, in France: this is according to a study published in 2024 by Dr. Christine Giacometti and her colleagues.From January 2010 to December 2022, researchers looked at 1,953 PLHIV monitored in six hospital centers: Clermont-Ferrand University Hospital and ul Linnes, Montluçon, Vichy, Aurillac, and Puy-en-Valley.Overall, over 12 years, the rate of participants using dual therapy increased from 5% to 22.5%, with the majority (82.7%) starting dual therapy after 2018.Primarily, PLHIV who benefited from this reduction strategy were men (almost three times more);The mean age was 61 years, had other comorbidities (diabetes, depression, renal failure, etc.) and had been infected for many years.
Special tracking?
"Yes," replied Dr.jacometAs with any change in treatment, monitoring is increased slightly for 6 months by checking the viral load (amount of HIV in the blood) at 1 month and 6 months in infected patients controlled under triple therapy.After that, we examine PhIV every 3 months for a year to ensure good tolerance, efficacy and no treatment toxicity.
How do you make a choice between the different options?
During a discussion between the doctor and the PLHIV, knowing that it depends on the needs and preferences of the PLHIV."For example, if there is difficulty in taking one oral treatment every day, we will offer a double injectable treatment every two months. But this option may be prohibitive for people who are resistant to injections or who cannot scrupulously adhere to the injection frequency due to, for example, frequent travel. In terms of choosing between two double oral treatments, it depends on whether or not the history of injection-resistant treatments is idiopathic or not, thePLHIV tolerate one better than the other,” explains Dr. Palich.
What was the news about the new drug at the ECCS conference in October?
It is a comprehensive treatment that is taken only once ... once a week - and not like an oral treatment every day.Dr. Pulich said, "Made by the American Amermomeutical Laboratory of AMS. take the treatment correctly.
Two Phase 3 trials, the final stage in the evaluation of new drugs, are now underway, each of which is infected with HIV.If the above results are confirmed, this dual therapy can be a weekly oral treatment.
[i] In the past, dual therapy was available to humans through clinical research projects.
